A Short Study of Psalm 53:1
“The fool hath said in his heart, There is no God.” (Psalm 53:1)
In the King James Version, the words, “there is”, are in italics, which indicates that those two words were added by the translators to make the text read more smoothly. Remove the italicized words, and this is what the sentence before us says: “The fool hath said in his heart, No God.” How telling. This is the language of the fool: “No God! No God! No God for me! I will not bow. I will not submit. I will not obey. I will not conform.” I say to you, don’t be a fool. God is, and one way or another, all will bow and submit to Him, even those who foolishly say, “No God.”
“I am God, and there is none else.” (Isaiah 45:22; Isaiah 46:9)
There is, however, another possible meaning. Add a comma between no and God, and this is what the text says: “The fool hath said in his heart, No, God.” Only a fool says, “No God,” and only a fool says no to God. Only a fool disagrees with God Almighty, and needless to say, there are plenty of fools in this world.
God says that Jesus Christ put away the sins of His people, and only the sins of His people (Psalm 103:12; Isaiah 38;17; Micah 7:18-20; Hebrews 9:26; Hebrews 10:17; 1st John 1:7), but the fool says, “No, Christ died to make redemption possible for all men, so that all men might have a fair chance to get saved.”
God says that there are none good, no, not even one (Psalm 53:1; Romans 3:10-12), but the fool says, “No, that’s not true. There is at least one, and I am he.”
God says that by the works of the law shall no flesh be justified in His sight (Romans 3:20; Psalm 143:2; Acts 13:39; Galatians 2:16; Galatians 3:11; Galatians 5:4), but the fool says, “No, that’s not right. Do your best, and God will save you.”
God says He loved Jacob and hated Esau (Romans 9:13), but the fool says, “No, God loves everybody.”
God says that the earth is a stationary, immovable circle (1st Chronicles 16:30; Psalm 93:1; Psalm 96:10; Psalm 104:5; Isaiah 45:18; Isaiah 40:22), but the fool says, “No, the earth is a moving, spinning, oblate spheroid.”
Fools say no to God, but the wise man says, “Let God be true and every man a liar.” (Romans 3:4)
Oh, foolish man, how long will you love simplicity? How long will you persist in your scorning? How long will you foolishly hate knowledge? Why do you take sides with the devil against the only one who can do you good? Do you honestly believe that you can win this fight? Wake up, and get real. Why do you hate your own soul? Why do you love darkness and hate the light? Why, oh, why do you insist on fighting a losing battle with your Maker? Consider this: “God is light,” and He can never lie. You are wrong, and you cannot overthrow God, God’s throne, God’s word, or God’s truth. What God says is true, and just, and good, and it behooves us all to receive His word straightway with all eagerness and readiness of mind, for this is right. Regardless of what the wise men of this world think, feel, or say, what God says is final.
Don’t be a fool. Don’t fight against God, for there is no wisdom, power, or might that can successfully withstand His excellent majesty. Don’t throw your soul away (Isaiah 8:20; Matthew 16:26; 2nd John 9; Revelation 22:18-19). God is smarter than you, bigger than you, more righteous than you, and infinitely more powerful than you. Be wise, therefore, and submit yourself to Him with all speed and fidelity. Be wise, and submit your reason to His revelation. Never again say no to God; simply believe Him. This is wisdom, and this is salvation (John 6:47; John 8:47; John 10:4-5).
(Adapted)
Test All Things 
“He that is of God heareth God’s words: ye therefore hear them not, because ye are not of God.” (John 8:47)
“And when he putteth forth his own sheep, he goeth before them, and the sheep follow him: for they know his voice. And a stranger will they not follow, but will flee from him, for they know not the voice of strangers.” (John 10:4-5)